Fair Value, Hierarchy [Axis] Level 2 Level 3 Level 1 Class of Warrant or Right [Axis] Warrants Options Restricted stock Equity Components [Axis] Common Stock Additional Paid-In Capital Exercise Price Range [Axis] Exercise Price $10.60 to $63.20 Exercise Price $67.00 to $95.20 Exercise Price $96.40 to $113.00 Exercise Price $14.80 to $138.00 Investment Type [Axis] Corporate debt securities Accumulated other comprehensive gain (loss) Accumulated deficit Award Type [Axis] Stock Option [Member] Plan Stock Options [Member] Equity Interest Type [Axis] Common stock Income Tax Authority [Axis] Federal and State [Member] Document And Entity Information Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Is Entity a Well-known Seasoned Issuer? Is Entity a Voluntary Filer? Is Entity's Reporting Status Current? Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Period Focus Document Fiscal Year Focus Statement of Financial Position [Abstract] ASSETS Current assets Cash and cash equivalents Marketable securities Accounts receivable Prepaid expenses Total current assets Marketable securities Property and equipment, net Other assets Total assets LIABILITIES AND STOCKHOLDERS' EQUITY Current liabilities Accounts payable Accrued liabilities Warrant liabilities Total current liabilities Total liabilities Commitments and contingencies; see Note I Stockholders' equity Common stock, par value $.0001 per share; authorized 400,000,000 shares; issued and outstanding 1,411,840 and 1,406,002, respectively Additional paid-in capital Accumulated other comprehensive loss Accumulated deficit Total stockholders' equity Total liabilities and stockholders' equity Common stock, par value Common stock, authorized Common stock, issued Common stock, outstanding AvailableForSaleSecuritiesEstimatedFairValue Operating expenses General and administrative Research and development Loss on impairment of long-lived assets Total operating expenses Net operating loss Interest expense Other income Income tax benefit Net loss Unrealized gain on marketable securities Total comprehensive loss Net loss per share, basic and diluted Weighted average number of common shares outstanding, basic and diluted Statement [Table] Statement [Line Items] Additional paid-in capital Beginning Balance, Shares Beginning Balance, Amount Compensation on options and restricted stocks issued, Share Compensation on options and restricted stocks issued, Amount Par value adjustment due to reverse stock split Unrealized gain on marketable securities Net income (loss) Ending Balance, Shares Ending Balance, Amount Statement of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES Net Loss Adjustments to reconcile net loss to net cash used in operating activities Depreciation and amortization Loss on impairment, disposal and write down of long-lived assets Loss (Gain) on disposal of property and equipment Issuance and vesting of compensatory stock options and warrants Issuance of common stock as compensation Change in the fair value of warrants Amortization of premium on marketable securities Deferred income taxes Changes in operating assets and liabilities Accounts receivable, prepaid expenses and other assets Accounts payable and accrued liabilities Net cash used in operating activities CASH FLOWS FROM INVESTING ACTIVITIES Purchase of marketable securities Sale of marketable securities Purchase of property and equipment Proceeds from the sale of property and equipment Net cash provided by (used in) investing activities Net change in cash and cash equivalents Cash and cash equivalents, beginning of period Cash and cash equivalents, end of period Accounting Policies [Abstract] DESCRIPTION OF BUSINESS SUMMARY OF CRITICAL ACCOUNTING POLICIES Notes to Financial Statements BALANCE SHEET COMPONENTS Goodwill and Intangible Assets Disclosure [Abstract] INTANGIBLE ASSETS Equity [Abstract] STOCKHOLDERS' EQUITY Commitments and Contingencies Disclosure [Abstract] COMMITMENTS AND CONTINGENCIES Retirement Benefits [Abstract] 401(k) BENEFIT PLAN Income Tax Disclosure [Abstract] INCOME TAXES I. Subsequent Events SUBSEQUENT EVENTS Use of Estimates Principles of Consolidation Goodwill Cash and Cash Equivalents Cash Concentration Risk Liquidity and Capital Resources Deferred financing costs Derivative financial instruments Beneficial conversion and warrant valuation Preclinical Study and Clinical Accruals Property and Equipment, Net Revenue Recognition Research and Development Costs Income Taxes Stock-Based Compensation Loss per Share Operating Leases Recent Accounting Pronouncements Fair Value Investments in Marketable Securities Warrant liability Change in Fiscal Year Anti-dilutive securities Fair values of investments by type Scheduled of investments maturity Significant Unobservable Inputs Summary of warrant derivative liability Fair Value Measurements Property Plant and Equipment Accrued Liabilities Warrant Activity Shares available for grant under the Plan Outstanding stock options Options Activity Options vested and expected to vest Fair Value Assumptions Stock options Restricted Stock Grants F. Commitments And Contingencies Tables Future lease payments Provision for income taxes Reconciliation of income tax expenses (benefit) Deferred tax assets Convertible note Anti-dilutive securities Amortized Cost Accrued Interest Gross Unrealized Gains Gross Unrealized losses Estimated Fair Value B. Summary Of Critical Accounting Policies Details 2 Maturing in one year or less Maturing after one year through three years Total investments B. Summary Of Critical Accounting Policies Details 3 Closing stock price Expected dividend rate Expected stock price volatility Risk-free interest rate Expected life (years) Current Assets Cash and cash equivalents Marketable securities Long-term Assets Marketable securities Current Liabilities Warrant liabilities B. Summary Of Critical Accounting Policies Details Narrative Uninsured FDIC Current assets Working capital Cash Loss in marketable securities recognised Fair value of the warrant liability Change in fair value gain (loss) C. Balance Sheet Components Details Laboratory equipment Computer equipment and software Office furniture and fixtures Subtotal Less: Accumulated depreciation Property Plant and Equipment C. Balance Sheet Components Details 1 Operating costs Employee related Total Depreciation and amortization expense E. Stockholders Equity Details Number of Warrants Outstanding, Beginning Number of Warrants Issued Number of Warrants Exercised Number of Warrants Forfeited Number of Warrants Outstanding, Ending Weighted Average Exercise Price Outstanding, Beginning Weighted Average Exercise Price Issued Weighted Average Exercise Price Exercised Weighted Average Exercise Price Forfeited Weighted Average Exercise Price Outstanding, Ending Exercise of warrants 1999 Amended Stock Plan Shares available for grant. Beginning Balance Additional shares reserved Options granted Options cancelled/forfeited Restricted stock granted Restricted stock cancelled/forfeited 1999 Amended Stock Plan Shares available for grant, Ending balance Number of Options Outstanding, Beginning Number of Options Granted Number of Options Cancelled Number of Options Outstanding, Ending Weighted Average Exercise Price Outstanding, Beginning Weighted Average Exercise Price Granted Weighted Average Exercise Price Canceled Weighted Average Exercise Price Outstanding, Ending Aggregate Intrinsic Value Weighted Average Remaining Contractual Life (Years) Number of Options Exercisable and Vested Options Exercisable and Vested Weighted Average Exercise Price E. Stockholders Equity Details 4 Number of Option Shares Vested Weighted Average Exercise Price Vested Aggregate Intrinsic Value Vested Weighted Average Remaining Contractual Life (Years) Vested Number of Option Shares Vested and expected to vest Weighted Average Exercise Price Vested and expected to vest Aggregate Intrinsic Value Vested and expected to vest Weighted Average Remaining Contractual Life (Years) Vested and expected to vest Gain included in income from change in fair value of warrants for the period Risk-free interest rate (weighted average) Expected volatility (weighted average) Expected term (in years) Expected dividend yield Options granted Options exercised Options forfeited or expired Options exercisable Weighted Average Exercise Price, Option granted Weighted Average Exercise Price, Options exercised Weighted Average Exercise Price, Options forfeited or expired Weighted Average Exercise Price, Options exercisable Ending Balance Number of Restricted Stock Grants, Beginning Granted Vested Cancelled Forfeited Number of Restricted Stock Grants Ending Weighted Average Grant Date Fair Value, Beginning Weighted Average Grant Date Fair Value, Granted Weighted Average Grant Date Fair Value, Vested Weighted Average Grant Date Fair Value, Cancelled Weighted Average Grant Date Fair Value, Forfeited Weighted Average Grant Date Fair Value, Ending Class of Stock [Axis] Common stock value Common stock, shares outstanding Warrants outstanding Fair value of warrant liability Common stock available for grant Inducement stock option compensation expense Remaining unrecognized compensation expense related to inducement stock options Inducement stock options outstanding, Weighted Average Remaining Contractual Term Compensation expense for restricted stock grants Unrecognized compensation costs related to non-vested restricted stock grants Weighted-average grant-date fair value of options granted F. Commitments And Contingencies Details 2018 2019 2020 2021 2022 2023 Total Total rent expense Matching contributions expense for Retirement Savings Plan H. Income Taxes Details Current federal income tax expense Deferred federal income tax benefit Provision for federal income taxes: Current state income tax expense Deferred state income tax benefit Provision for state income taxes: Total U.S. federal taxes (benefit) at statutory rate State income tax benefit, net of federal benefit Stock compensation Other nondeductible, including goodwill impairment Change in state tax rate Change in the federal tax rate Federal and state net operating loss adjustments Other, including expiration of NOL carryforwards Change in valuation allowance Income tax Deferred tax assets Net operating Loss Carryforwards Accruals and others Capital loss carryoforwards Valuation allowance Net deferred tax assets Deferred Tax Liabilities IPR&D Other liabilities Net Deferred Tax Liabilities Operating loss carryforwards Operating loss carryforwards, expiration dates Custom Element. Custom Element. Custom Element. Custom Element. Custom Element. Custom Element. 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Assets, Current Marketable Securities, Noncurrent Assets Liabilities, Current Liabilities Retained Earnings (Accumulated Deficit) Stockholders' Equity Attributable to Parent Liabilities and Equity Operating Expenses Operating Income (Loss) Other Nonoperating Income (Expense) Shares, Issued Marketable Securities, Unrealized Gain (Loss) Gain (Loss) on Disposition of Property Plant Equipment ChangeInFairValueOfWarrants1 Increase (Decrease) in Prepaid Expense and Other Assets Net Cash Provided by (Used in) Operating Activities Payments to Acquire Marketable Securities SaleOfMarketableSecurities Payments to Acquire Property, Plant, and Equipment Net Cash Provided by (Used in) Investing Activities Cash and Cash Equivalents, Period Increase (Decrease) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Available-for-sale Securities, Amortized Cost Basis Accrued Investment Income Receivable AvailableForSaleSecuritiesEstimatedFairValue [Default Label] Cash and Cash Equivalents, Fair Value Disclosure Available-for-sale Securities Investments, Fair Value Disclosure Derivative Liability Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment NumberOfWarrantsOutstandingBeginning NumberOfWarrantsOutstandingEnding WeightedAverageExercisePriceOutstandingBeginning WeightedAverageExercisePriceOutstandingEnding AmendedStockPlanSharesAvailableForGrant Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Options Forfeited, Number of Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Gain included in income from change in fair value of warrants for the period [Default Label] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value OperatingLeasesFutureMinimumPaymentDue Current Federal, State and Local, Tax Expense (Benefit) Deferred Tax Assets, Valuation Allowance Issuance of warrants Other Liabilities Deferred Tax Liabilities, Net